Assistant Professor
Dr Muhammad Zaman Ashraf
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051-9057182
zaman.ashraf@aiou.edu.pk

Education

PhD

Quaid--Azam University Islamabad 

Postdoc 

Kongju National University, Gongju South Korea

Experience

Dr Muhammad Zaman Ashraf s/o Muhammad Ashraf, working as Assistant Professor at Chemistry Department, Allama Iqbal Open University, Islamabad. I have completed my M.Phil in Organic Chemistry from Quaid-I-Azam University, Islamabad in 2003. The research work I have accomplished in MPhil includes synthesis and characterization of liquid crystalline material. I have completed my PhD degree from Quaid-I-Azam University, Islamabad in 2011. I have been awarded Postdoctoral fellowship (Brain Korea 21 plus BK-21 Plus) at Kongju National University, Gongju South Korea from June 2014 to March 2016.   

Publications

    1. Yasir Nazir, Hummera Rafique, Sadia Roshan, Shazia Shamas, Zaman Ashraf*, Muhammad Rafiq, Tehreem Tahir, Zia-Ur-Rahman Qureshi, Alvina Aslam, and Muhammad Hassham Hassan Bin Asad. Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis. BioMed Research International. 2022, Article ID 1040693.
    2. Sadia Abbas, Saira Afzal, Humaira Nadeem, Dilawar Hussain, Peter Langer, Jean Sévigny, Zaman Ashraf*, Jamshed Iqbal. Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors. Bioorganic Chemistry. Volume 118, January 2022, 105456.
    3. Reem Altaf, Humaira Nadeem, Muhammad Nasir Iqbal, Umair Ilyas, Zaman Ashraf, Muhammad Imran, and Syed Aun Muhammad. Synthesis, Biological Evaluation, 2D-QSAR, and Molecular Simulation Studies of Dihydropyrimidinone Derivatives as Alkaline Phosphatase Inhibitors. ACS Omega 2022, 7, 7139−7154.
    4. Muhammad Tahir Aqeel1, Nisar-Ur-Rahman, Arif-ullah Khan, Zaman Ashraf, Samiullah Khan and Muazzam Arif. In silico approach for the development of phenolic derivatives as potential anti-angiogenic agents against lysyl oxidase-like 2 enzyme. Future Journal of Pharmaceutical Sciences (2022) 8:32.
    5. Yasir Nazir, Hummera Rafique, Naghmana Kausar, Qamar Abbas, Zaman Ashraf*, Pornchai Rachtanapun, Kittisak Jantanasakulwong and Warintorn Ruksiriwanich. Methoxy-Substituted Tyramine Derivatives Synthesis, Computational Studies and Tyrosinase Inhibitory Kinetics. Molecules, Vol. 26, 2477, 2021.
    6. Mujahid Abas, Ali Bahadur, Zaman Ashraf*, Shahid Iqbal, Muhammad Shahid Riaz Rajoka, S.G. Rashid, Erum Jabeen, Zafar Iqbal, Qamar Abbas, Abdul Bais, Mubashir Hassan, Guocong Liu, Kejun Feng, Sang Hee Lee, Muhammad Nawaz, Muhammad Abdul Qayyum. Designing novel anticancer sulfonamide based 2,5-disubstituted-1,3,4-thiadiazole derivatives as potential carbonic anhydrase inhibitor. Journal of Molecular Structure 1246 (2021) 131145.
    7. Mujahid Abas, Yasir Nazir, Zaman Ashraf,* Zafar Iqbal, Hussain Raza, Mubashir Hassan, Erum Jabeen, and Abdul Bais. A Practical Method of N-ethylpyrrole Disulfonamides Synthesis: Computational Studies, Carbonic Anhydrase Inhibition and Electrochemical DNA Binding Investigations. ChemistrySelect 2021, 6, 7376 –7383.
    8. Jamshaid Ashraf, Ehsan Ullah Mughal, Reem I. Alsantali, Amina Sadiq, Rabab. S. Jassas, Nafeesa Naeem, Zaman Ashraf,* Yasir Nazir, Muhammad Naveed Zafar, Amara Mumtaz, Masoud Mirzaei, Satar Saberij and Saleh A. Ahmed. 2-Benzylidenebenzofuran-3(2H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational studies RSC Adv., 2021, 11, 35077.
    9. Atteeque Ahmed, Aamer Saeed, Omar M. Ali, Zeinhom M. El-Bahy, Pervaiz Ali Channar, Asma Khurshid, Arfa Tehzeeb, Zaman Ashraf, Hussain Raza, Anwar Ul-Hamid and Mubashir Hassan. Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure–Activity Relationship (SAR) Studies. Molecules 2021, 26, 7150.
    10. Nadeem Irshad, Arif-ullah Khan, Fawad Ali Shah, Humaira Nadeem, Zaman Ashraf, Muhammad Khalid Tipu, Shupeng Li. Antihyperlipidemic effect of selected pyrimidine derivatives mediated through multiple pathways, Fundam Clin Pharmacol. 1–14. 2021
    11. Tayyaba Habib , Maria Zubair , Salma Bilquees , Asma Iqbal , Humaira Masood Siddiqi , Zaman Ashraf & Naveed Kausar Janjua. Polyimides with noncoplanar Carbazole-TPA units: synthesis and characterization. Polymer-Plastics Technology and Materials, Vol. 60, 534–547, 2021.
    12. Asma Khurshid, Aamer Saeed, Zaman Ashraf, Qamar Abbas, Mubashir Hassan. Understanding the enzymatic inhibition of intestinal alkaline phosphatase by aminophenazone‑derived aryl thioureas with aided computational molecular dynamics simulations: synthesis, characterization, SAR and kinetic profiling. Molecular Diversity (2021) 25:1701–1715.
    13. Sumbal Iqbal, Fawad Ali Shah, Komal Naeem, Humaira Nadeem, Sadia Sarwar, Zaman Ashraf, Muhammad Imran, Tariq Khan, Tayyaba Anwar and Shupeng Li. Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration. Biomolecules. Vol. 10, 443, 2020.
    14. Yasir Nazir, Aamer Saeed, Muhammad Rafiq, Samina Afzal, Anser Ali, Muhammad Latif, Johannes Zuegg, Waleed M. Husseinh, Christian Fercher, Ross T. Barnard, Matthew A. Cooper, Mark A.T. Blaskovich, Zaman Ashraf*, Zyta M. Ziora. Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic & Medicinal Chemistry Letters 30 (2020) 126722.
    15. Tanzeela A. Fattah, Aamer Saeed, Zaman Ashraf*, Qamar Abbas, Pervaiz A. Channar, Fayaz A. Larik and Mubashir Hassan. 4-Aminocoumarin based Aroylthioureas as Potential Jack Bean Urease Inhibitors; Synthesis, Enzyme Inhibitory Kinetics and Docking Studies. Medicinal Chemistry, 2020, 16, 2, 229-243.
    16. Mujahid Abas, Hummera Rafique, Shazia Shamas, Sadia Roshan, Zaman Ashraf*, Zafar Iqbal, Hussain Raza, Mubashir Hassan, Khurram Afzal, Albert A. Rizvanov and Muhammad Hassham Hassan Bin Asad. Sulfonamide-Based Azaheterocyclic Schiff Base Derivatives as Potential Carbonic Anhydrase Inhibitors: Synthesis, Cytotoxicity, and Enzyme Inhibitory Kinetics. BioMed Research International. 2020, Article ID 8104107, 1-9.
    17. Shams-Ul Mahmood,Yasir Nazir, Aamer Saeed, Qamar Abbas, and Zaman Ashraf*. Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Coumarinylthiazolyl Iminothiazolidinone Hybrids as Potent Urease Inhibitors. ChemistrySelect 2020, 5, 5387 –5390.
    18. Muhammad Rashid, Hummera Rafique, Sadia Roshan, Shazia Shamas, Zafar Iqbal, Zaman Ashraf*, Qamar Abbas, Mubashir Hassan, Zia Ur Rahman Qureshi, and Muhammad Hassham Hassan Bin Asad. Enzyme Inhibitory Kinetics and Molecular Docking Studies of Halo-Substituted Mixed ester/Amide-Based Derivatives as JackBean Urease Inhibitors. BioMed Research International. 2020, Article ID 8867407, 1-11.
    19. Naila Khalid, Sahar Shumail, Humaira Masood Siddiqi, Romana Qureshi, Zaman Ashraf. Triphenylamine based redox-active, fluorescent polyamides: synthesis and photophysics. Journal of Polymer Research, Vol. 27, Page 51, 2020.
    20. Naghmana Kausar, Shahzad Murtaza, Muhammad Nadeem Arshad, Robina Rashid, Abdullah M. Asiri, Noman Javid, Mulazim Hussain Asim, Zaman Ashraf. Journal of Molecular Structure, Vol. 1210, 128042, 2020.
    21. Naghmana Rashid, Almas Kiran, Iqbal Ahmad, Zaman Ashraf, Bohari Mohd. Yamin, and Muhammad Rafiq. Synthesis, DFT, electrochemical, biological and DNA-interaction studies of a novel copper(II) complex of salicylic acid and N-tosyl substituted benzimidazole. Journal of Coordination Chemistry. Vol. 73, 52, 2020. 
    22. Saba Ashraf, Aamer Saeed, Seong-Hee Moon, Ulrich Florke, Seong Hwan Kim, Zaman Ashraf, Muhammad Yaseen, and Muhammad Latif. Design, Synthesis and Biological Evaluation of 2-(naphthoyl) iminothiazolidin-4-ones as Potential Anticancer Agents. Design, Synthesis and Biological Evaluation of 2-(naphthoyl) iminothiazolidin-4-ones as Potential Anticancer Agents. Chemistryselect, Vol. 5, 5387-5390, 2020.         
    23. Bushra Nosheen, Fouzia Perveen, Zaman Ashraf, Abdul Bais, Tayyaba Noor. Charge transfer and opto-electronic properties of some newly designed polycatenar discotic liquid crystal derivatives: a DFT study. Journal of Molecular Modeling, Vol. 26, 291, 2020.
    24. Hasil Aman, Naghmana Rashid, Zaman Ashraf, Aamna Bibi, Hsin-Tsung Chen, Nadaraj Sathishkumar. Synthesis, density functional theory (DFT) studies and urease inhibition activity of chiral benzimidazoles. Heliyon, Vol.6  e05187, 2020
    25. Humaira Rafiq, Aamer Saeed, Fouzia Perveen, Naghma Kausar, Zaman Ashraf, Sadia Akram, Muhammad Naveed Zafar, Muhammad Tayyab, Ulrich Florich. Design, Synthesis, Crystal Structure, Fluorescence, Molecular Docking and DFT Studies of 3,6-Dinitro-N-octylcarbazole.  Current Organic Chemistry, Volume 23 , Issue 15 , 2019.
    26. Muhammad Tahir Aqeel, Nisar-ur-Rahman, Arif-ullah Khan, Ashfaq Ahmad, Zaman ashraf, Usman Rasheed and Sibghat Mansoor. Phenolic Derivatives with Antioxidant and Anti-Inflammatory Activities: An in Silico, in vitro and in vivo Study. DOI: 10.29261/pakvetj/2019:052.
    27. Anser Ali, Zaman Ashraf, Muhammad Rafiq, Ajeet Kumar, Farukh Jabeen, Goon Joon Lee, Fahad Nazir, Mushtaq Ahmed, Myungchull Rhee and Eun Ha Choi. Novel Amide Derivatives as Potent Tyrosinase Inhibitors; In-vitro, In-vivo Antimelanogenic Activity and Computational Studies. Medicinal Chemistry, 2019, 15, 1-15.
    28. Zafar Iqbal, Zaman Ashraf*, Mujahid Abas, Muhammad Nawaz Tahir, Erum Jabeen, Rehan Zafar Paracha, Maryum Nisar, Safeer Ahmad. Synthesis, crystal structure and DNA binding interactions of ethyl 2-(2-acetamidothiazol-4-yl) acetate: theoretical and experimental investigations. Journal of Molecular Structure. https://doi.org/10.1016/j.molstruc.2019.126903.
    29. Muhammad Rafiq, Yasir Nazir, Zaman Ashraf*, Hummera Rafique, Samina Afzal, Amara Mumtaz, Mubashir Hassan, Anser Ali, Khurram Afzal, Muhammad Rizwan Yousuf, Muhammad Saleem, Katarzyna Kotwica-Mojzych & Mariusz Mojzych. Synthesis, computational studies, tyrosinase inhibitory kinetics and antimelanogenic activity of hydroxy substituted 2-[(4-acetylphenyl)amino]-2-oxoethyl derivatives, Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, VOL. 34, NO. 1, 1562–1572.
    30. Zafar Iqbal, Ambreen Iqbal, Zaman Ashraf*, Muhammad Latif, Mubashir Hassan, Humaira Nadeem. Synthesis and docking studies of N-(5-(alkylthio)-1,3,4-oxadiazol-2-yl)methyl)benzamide analogues as potential alkaline phosphatase inhibitors. Drug Dev Res. 2019; 80:646–654
    31. Zaman Ashraf, Tariq Mahmood, Mubashir Hassan, Samina Afzal, Hummera Rafique, Khurram Afzal, Jalifah Latip. Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation. Drug Design, Development and Therapy 2019:13 1643–1657.
    32. Erum Jabeen, Naveed K. Janjua, Safeer Ahmed, Tahir Ali, Iram Murtaza, Zaman Ashraf*, Nosheen Masood, and Saima Kalsoom. Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co-Administration of β-Cyclodextrin. Chemistry Select 2019, 4, 9420 –9432.
    33. Pervaiz Ali Channar, Hina Irum, Abid Mahmood, Ghulam Shabir, Sumera Zaib, Aamer Saeed, Zaman Ashraf, Fayaz Ali Larik, Joanna Leckad, Jean Sevignyd, Jamshed Iqbal. Design, synthesis and biological evaluation of trinary benzocoumarinthiazoles- azomethines derivatives as effective and selective inhibitors of alkaline phosphatase. Bioorganic Chemistry 91 (2019) 103137.
    34. Zafar Iqbal, Zaman Ashraf*, Mubashir Hassan, Qamar Abbas, Erum Jabeen. Substituted phenyl[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetates/acetamides as alkaline phosphatase inhibitors: Synthesis, computational studies, enzyme inhibitory kinetics and DNA binding studies. Bioorganic Chemistry 90 (2019) 103108
    35. Aamer Saeed, Zaman Ashraf, Humaira Nadeem, Jim Simpson, Hiram Perez, Mauricio F. Erben. An investigation of supramolecular synthons in 1,2,4-triazole-3(4H)-thione compounds. X-ray crystal structures, energetic and Hirshfeld surface analysis.  Journal of Molecular Structure 1195 (2019) 796-806.
    36. Abdul bais, Zaman Ashraf*, Muhammad Nawaz Tahir, Fouzia Perveen, Mujahid Abbas, Imtiaz Ahmad.  Synthesis, single crystal X-ray structure and thermal analysis of a novel polycatenar liquid crystal: Theoretical and experimental approaches. Journal of Molecular Structure 1177 (2019) 1-8.
    37. Shereena Shahid, Muhammad Faisal, Aamer Saeed, Sarfaraz Ali Ghumro, Hesham R. El-Seedi,Samina Rasheed, Nadir Abbas, Fayaz Ali Larik, Pervaiz Ali Channar, Tanzeela Abdul Fattah, Zaman Ashraf, Zulfiqar Ali Solangi. A review on the Scope of Fluorinated Selective and Reactive TFDO-Mediated Oxidation in Organic Synthesis. Current organic synthesis, 15, 1091, 2019.
    38. Rabia Qamar, Aamer Saeed, Maria Saeed, Babar Hussain Shah, Zaman Ashraf*, Qamar Abbas, Sung Yum Seo. Synthesis and enzyme inhibitory kinetics of some novel 3-(substituted benzoyl)-2-thioxoimidazolidin-4-one derivatives as α-glucosidase/α-amylase inhibitors. Medicinal Chemistry Research (2018), 27, 1528-1537.
    39. Rabia Qamar, Aamer Saeed, Maria Saeed, Zaman Ashraf*, Qamar Abbas, Mubashir Hassan, Fernando Albericio. Synthesis, carbonic anhydrase inhibitory activity and antioxidant activity of some 1,3-oxazine derivatives. Drug Dev Res. 2018;79:352–361.
    40. Muhammad Tahir Aqeel, Nisar-ur-Rahman, Arifullah Khan, Zaman Ashraf*, Muhammad Latif, Humaira Rafique, Usman Rasheed. Anti-hyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches. Drug Design, Development and Therapy 2018:12 2443-2453.
    41. Muhammad Latif, Zaman Ashraf, Sulman Basit, Abdul Ghaffar, Muhammad Sohail Zafar, Aamer Saeed and Sultan Ayoub Meo. Latest perspectives of orally bioavailable 2,4-diarylaminopyrimidine analogues (DAAPalogues) as anaplastic lymphoma kinase inhibitors: discovery and clinical developments. RSC Adv., 2018, 8, 16470–16493.
    42. Naghmana Rashid, Almas Kiran, Zaman Ashraf, Moazzam Hussain Bhatti, Bushra Mirza, Hammad Ismail, Muhammad Rafiq and Jerry P. Jasinski.  Synthesis, Characterization, Antitumor, Antibacterial and Urease Inhibitory Activity of a Small Series of N-tosyl benzimidazoles. J.Chem.Soc.Pak., Vol. 40, No. 02, 2018, 366-374.
    43. Mubashir Hassan, Zaman Ashraf, Qamar Abbas, Hussain Raza, Sung-Yum Seo. Exploration of Novel Human Tyrosinase Inhibitors by Molecular Modeling, Docking and Simulation Studies. Interdiscip Sci Comput Life Sci (2018) 10:68–80.
    44. M. Hassan, M. Azhar, Q. Abbas, H. Raza, A.A. Moustafa, S. Shahzadi,  Zaman Ashraf and S.Y. Seo. Finding Novel Anti-carcinomas Compounds by Targeting SFRP4 Through Molecular Modeling, Docking and Dynamic Simulation Studies. Current Computer-Aided Drug Design, 2018, 14, 160-173.
    45. Pervaiz Ali Channar, Aamer Saeed, Fayaz Ali Larik, Bakhtawar Batool, Saima Kalsoom, M.M. Hasan, Mauricio F. Erben, Hesham R. El-Seedi, Musrat Ali, Zaman Ashraf. Synthesis of aryl pyrazole via Suzuki coupling reaction, in vitro mushroom tyrosinase enzyme inhibition assay and in silico comparative molecular docking analysis with Kojic acid. Bioorganic chemistry, 79, 2018, 293-300.
    46. Tanzeela Abdul Fattah, Aamer Saeed, Pervaiz Ali Channar, Zaman Ashraf, Qamar Abbas, Mubashir Hassan, Fayaz Ali Larik. Synthesis, enzyme inhibitory kinetics, and computational studies of novel 1-(2-(4-isobutylphenyl)propanoyl)-3-arylthioureas as Jack bean urease inhibitors. Chem Biol Drug Des. 2018; 91:434–447.
    47. Qamar Abbas, Zaman Ashraf, Mubashir Hassan, Humaira Nadeem, Muhammad Latif, Samina Afzal, Sung-Yum Seo. Development of highly potent melanogensis inhibitor by in vitro, in vivo and computational studies. Drug Design Development and Therapy, 2017, 11, 2029-2-46.
    48. Zaman Ashraf, Muhammad Rafiq, Humaira Nadeem, Mubashir Hassan, Samina Afzal, Muhammad Waseem, Khurram Afzal, Jalifah Latip. Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies. Plos One, 2017, 12(5): e0178069.
    49. Sulman Basit, Zaman Ashraf, Kwangho Lee, Muhammad Latif. First macrocyclic 3rd-generation ALK inhibitor for treatment of ALK/ROS1 cancer: Clinical and designing strategy update of lorlatinib. European Journal of Medicinal Chemistry 134 (2017) 348-356.
    50. Pervaiz Ali Channar, Aamer Saeed, Fayaz Ali Larik, Muhammad Rafiq, Zaman Ashraf, Farukh Jabeen, Tanzeela Abdul Fattah. Synthesis, computational studies and enzyme inhibitory kinetics of substituted methyl[2-(4-dimethylamino-benzylidene)-hydrazono)-4-oxo-thiazolidin-5-ylidene]acetates as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry 25 (2017) 5929–5938.
    51. Nasima Arshad, Muhammad Zafran, Zaman Ashraf, Fouzia Perveen. Synthesis, Characterization of amide substituted dexibuprofen derivatives and their spectral, voltametric and docking investigations for DNA binding interactions. Journal of Photochemistry and Photobiology B: Biology, 2017, 169, 134–147.
    52. Mubashir Hassan, Qamar Abbas, Zaman Ashraf, Ahmed A. Moustafa and Sung Yum Seo. "Pharmacoinformatics exploration of polyphenol oxidases leading to novel inhibitors by virtual screening and molecular dynamic simulation study. Computational Biology and Chemistry, 68 (2017) 131-142.
    53. Mubashir Hassan, Zaman Ashraf, Qamar Abbas and Sung Yum Seo. "Exploration of novel human tyrosinase inhibitors by molecular modeling, docking and simulation studies. Interdisciplinary Sciences: Computational Life Sciences, 2017 (Accepted).
    54. Aamer Saeed, Zaman Ashraf, Mauricio F. Erben, Jim Simpson. Vibrational spectra and molecular structure of isomeric 1-(adamantan-1-ylcarbonyl)-3-(dichlorophenyl)thioureas. Journal of Molecular Crystal, 1129 (2017), 283-291.

Project, Research Interests

I have been awarded a research project (Rs. 2.2million) from Higher Education Commission of Pakistan HEC. I have been successfully completed the project and HEC has been issued me the project completion certificate in 2019. I am currently working as Co-PI in another HEC funded project. I have published 98 research papers in good impact factor journals having international repute, 10 of my research papers are under consideration in different journals.  Four of my PhD students have completed their research work under my supervision, one of them currently doing postdoctoral research in Thailand. Thirty students have completed their M.Phil research work under my supervision. I have developed research collaboration with Kongju National University South Korea, University of Queensland Australia and Universiti Kebangsaan Malaysia.

My research area is Organic and Medicinal Chemistry including drug development through enzyme based assays. We have developed a highly potent tyrosinase inhibitor in collaboration with South Korean and Australian research groups. Two of patents from this work have been submitted and are under review. One of my project is related to drug delivery system for NSAIDs, several prodrugs of these drugs have been synthesized and published from my research group. I am enthusiastic in teaching chemistry and doing research as well.

About

The Allama Iqbal Open University was established in May, 1974, with the main objectives of providing educational opportunities to masses and to those who cannot leave their homes and jobs. During all these past years, the University has more than fulfilled this promise.