The office was officially established on 1 January 2026 and is situated in Orangi Sector 10, opposite Ibrahim Ali Bhai School.

The territorial jurisdiction of this office comprises the following areas: Orangi Town, Mominabad, Manghopir, Banaras, Naya Nazimabad, Frontier Colony, Pakistan Bazaar, Iqbal Market, Sultanabad, and Ittehad Town. The office is responsible for providing services and carrying out its official functions within these designated areas.

Furthermore, the spring 2026 semester enrollment for District South is 8,340. MSC South facilitates students, tutors, and parents regarding their admissions.